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Importance of a One Health approach  …………………………………………………………………………………….  2 Role of Africa CDC and national public health institutes in improving public health …………. 5 Purpose of this One Health framework …………………………………………………………………………………….. 6 Section 1: Goals, objectives, and activities ………………………………………………………………………………..7 Goal #1: Strengthen multisectoral, One Health coordination and collaboration…………………. 7 Goal #2: Develop and strengthen surveillance systems and data-sharing mechanisms with relevant stakeholders………………………………………………………………………………………………………… 10 Goal #3: Strengthen Laboratory Systems and Network to ensure early detection, surveillance and response ……………………………………………………………………………………………………….. 15 Goal #4: Ensure effective and coordinated public health emergency preparedness and response using a One Health approach …………………………………………………………………………………..18 Goal #5: Strengthen and support workforce development to prevent and control priority zoonotic diseas …………………………………………………………………………………………………………….. 23 Section 2: One Health technical guidance………………………………………………………………………………. 27 General One Health considerations…………………………………………………………………………………………. 27 Considerations for commonly prioritized zoonotic diseases ……………………………………………… 30 Anthrax…………………………………………………………………………………………………………………………………………. 30 Brucellosis……………………………………………………………………………………………………………………………………. 33 Rabies ………………………………………………………………………………………………………………………………………….. 34 Viral haemorrhagic fevers …………………………………………………………………………………………………………. 42 Zoonotic influenzas ……………………………………………………………………………………………………………………..44 Cross-border considerations ………………………………………………………………………………………………………47 Section 3: Monitoring One Health progress………………………………………………………………………………48 One Health Scorecard ………………………………………………………………………………………………………………….50 Glossary of Terms ………………………………………………………………………………………………………………………..55 References …………………………………………………………………………………………………………………………………….59

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